AACC Webinar: Kidney Biomarkers and Shrunken Pore Syndrome*
29. Aug 2019 |
5 min read
The Use of Biomarkers in Chronic Kidney Disease and the Novel Disorder Shrunken Pore Syndrome (SPS)*
*this webinar is supported by Gentian
This AACC webinar* with Anders Grubb (MD, PhD, Professor in Clinical Chemistry, Lund University) focuses on renal biomarkers. Dr. Grubb will discuss the pros and cons of cystatin C and creatinine as kidney markers, and also share his insight about the novel disorder Shrunken Pore Syndrome (SPS):
How SPS is diagnosed
The mortality of SPS
The most common death causes associated with SPS
Hypotheses concerning its pathophysiology and treatment"
Kidney disorders are very common and represent a significant and growing clinical problem. Such disorders are usually diagnosed by identifying a decrease in estimated Glomerular Filtration Rate (eGFR) using a creatinine- or cystatin C-based estimating equation for GFR. Dr. Grubb will show how the best estimation is obtained by using the average value of a cystatin C-based and a creatinine-based GFR estimating equation.
Shrunken Pore Syndrome: Short introduction
Shrunken Pore Syndrome (SPS) was defined in 2015. The syndrome is characterised by the glomerular filtration of 5-40 kDa molecules being selectively decreased compared to that of molecules <0.2 kDa, e.g. water and creatinine. The mortality is strongly increased in all investigated populations and increases progressively with a decrease in the eGFRcystatin C/eGFRcreatinine ratio used to identify the syndrome. The syndrome might also explain the superiority of eGFRcystatin C over eGFRcreatinine in identifying high-risk kidney patients.
The Glomerular Filtration Rate (GFR) is the volume of primary urine produced per unit of time, corresponding to the volume of plasma filtered during that same time. GFR can’t be measured in humans, because it is not feasible to measure the filtration flow in the 800,000 human glomeruli. Diagnosis must therefore rely on estimations of GFR. Many potential markers for GFR are available, but only creatinine and cystatin C have been extensively evaluated.
P-Cystatin C and P-Creatinine: recommended as markers of GFR
Do you want to learn more about cystatin C in general or our cystatin C immunoassay. Our Product Manager for cystatin C is happy to answer all questions you might have. Fill out the form below or send an email to firstname.lastname@example.org.