COVID-19 and calprotectin's clinical value

21. Dec 2021 | 6 min read

COVID-19 and calprotectin's clinical value

Calprotectin as a valuable prognostic marker in care of COVID-19 patients

The rising numbers of SARS-CoV-2 infections during the recent weeks are again pushing the health systems to their limits. Early identification of infected patients who will develop severe COVID-19 can help hospitals to better allocate essential resources.

The role of calprotectin (plasma and serum) in early identification of neutrophil activation and hyper-inflammatory response in both COVID-19 and COVID-19 related sepsis has been confirmed in several studies. These research results indicate that calprotectin can be used in the risk assessment and prediction of which COVID-19 patients are at risk of developing severe complications such as respiratory failure and/or mortality.

Therefore, calprotectin can be used as a valuable biomarker for early evaluation of the disease severity and identification of patients at risk to progress to severe form of the disease, contributing to effective triage and care of COVID-19 patients.

Below you will find more information about plasma and serum calprotectin related to COVID-19. If you are interested in more information about calprotectin or in validation at your laboratory, please reach out to

WEBINAR: The role of calprotectin in COVID-19


HubSpot Video




FAQ: Why is calprotectin upregulated in COVID-19?

FAQ: What role can plasma & serum calprotectin play in severe COVID-19?

Studies Demonstrate Use of Gentian Calprotectin Test to Triage COVID-19 Patients

Study confirms significantly elevated levels of calprotectin in patients with severe COVID-19

The role of Calprotectin in COVID-19 – results from clinical studies

New study results confirm the value of calprotectin in management of COVID-19 patients

Multicenter study confirms calprotectin’s role in risk stratification in COVID-19


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GCAL® is an immunoassay applied to turbidimetry-based clinical chemistry platforms. It is an open channel assay, meaning it can be added to all clinical chemistry analysers.

  • CE-marked since 2017
  • IVDR registration in progress
  • Developed and manufactured by Gentian
  • Manufactured according to ISO 13485:2016

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SARS-CoV-2 Total Antibody Immunoassay

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