Cystatin C turbidimetric test

Gentian Cystatin C Immunoassay

A better estimated Glomerular Filtration Rate (eGFR) for all

Cystatin C - a more accurate eGFR

Cystatin C is a superior biomarker for assessing kidney function and Chronic Kidney Disease (CKD), offering greater accuracy than traditional kidney markers like creatinine. Unlike creatinine, Cystatin C is unaffected by muscle mass, diet, sex, race, or physical activity.^1-3 Creatinine levels often remain normal until about 50% of kidney function is lost.⁴ This lack of sensitivity to mild renal insufficiency creates a "creatinine blind area", that can lead to under diagnosis of early CKD (stages 1 and 2).⁵

Cystatin C - the ideal combination with creatinine

Combining creatinine and cystatin C values improves eGFR accuracy over using either marker alone.^6-8This integration enhances risk stratification for CKD patients, facilitates better resource allocation, such as nephrology referrals, medication dosage adjustments, and more comprehensive kidney function tests.⁹ Additionally, the combination strengthens the correlation between estimated GFR and risks like cardiovascular disease, end-stage renal disease progression, and mortality.¹⁰

Kidney health advocates and organizations embrace the benefits of cystatin C

Clinical use of cystatin C is recommended by the guidelines of the international organization KDIGO’s (Kidney Disease: Improving Global Outcomes). In the United States, the joint task force convened by the National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) to address the race disparity in people with CKD, similarly advocates for expanded use of cystatin C, alongside creatinine, to confirm eGFR and enhance clinical decision-making.

Both the KDIGO guidelines and the NKF-ASN task force recommendations for managing CKD, advocate for a more substantial role for cystatin C, alongside creatinine, in estimating GFR. They emphasize the necessity of employing the most precise GFR assessment, often achieved through a combination of creatinine and cystatin C when mGFR is not a desired option.

LEARN MORE ABOUT THE CLINICAL VALUE OF cystatin c

cystatin c, utility as an alternative to creatinine

Webinar: New research about cystatin C

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Cystatin C testing - Balancing additional costs against potential benefits

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KDIGO CKD 2024 guidelines: Combine cystatin C and creatinine

Gentian Cystatin C assay - easy integration to all labs

The Gentian Cystatin C Immunoassay (ERM-DA471/IFCC standardized) is a turbidimetric test for quantitative determination of cystatin C in human serum and plasma.

The open channel test that can be added to all major clinical chemistry analyzers.

ERM-DA471/IFCC standardized
Less interference due to avian antibodies
FDA 510(k) cleared since 2008, CE-marked and IVDR-certified

Free validation kit*

Does your organisation intend to perform for more than 1000 cystatin C tests per year on a clinical chemistry instrument with turbidimetric capabilities? If yes, contact us for a free* validation kit through the contact form below or send an email to marketing@gentian.com.

Contact us today for more information

Explore cystatin C in your clinical practice and laboratory - fill out the form or send an email to marketing@gentian.com for more information about the product, prices and free validation kit*

References:

Ebert N, Shlipak MG. Cystatin C is ready for clinical use. Curr Opin Nephrol Hypertens. 2020
Tangri N et al. Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate. Kidney Int. 2011
Grubb A. Cystatin C is Indispensable for Evaluation of Kidney Disease. EJIFCC. 2017
Zarbock A, Anders HJ. Acute kidney injury. Nat Rev Dis Primers. 2021
Schaeffner ES. et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012
Hsu CY et al. Race, Genetic Ancestry, and Estimating Kidney Function in CKD. N Engl J Med. 2021
Inker LA et al. New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race. N Engl J Med. 2021
Inker LA et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012
Murty MS et al. Serum cystatin C as a marker of renal function in detection of early acute kidney injury. Indian J Nephrol. 2013
Chen DC et al. Differential Associations of Cystatin C Versus Creatinine-Based Kidney Function With Risks of Cardiovascular Event and Mortality Among South Asian Individuals in the UK Biobank. J Am Heart Assoc. 2023

*Terms and conditions:
Sole Discretion. Gentian Diagnostics shall, in its sole and absolute discretion, determine whether or not to proceed with all or part of the offer, determine the distribution date and determine whether to modify or change terms of the offer, including, without limitation, the form, structure and terms of any transaction(s) to affect the offer or the timing of and conditions to the consummation of the offer.
Contingency. The offer of a free validation kit is contingent on (a) the Customer providing written and/or verbal confirmation of an intent to perform for more than 200 cystatin C tests per annum on clinical chemistry system with turbidimetric capabilities and (b) the Customer agreeing to share all data pertaining experiments conducted to evaluate performance of the Gentian Cystatin C Immunoassay.

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