Cystatin C - recommended by KDIGO and NICE

07. Jan 2021 | 6 min read

Cystatin C - recommended by KDIGO and NICE

Cystatin C is superior biomarker of renal function1 and it is recommended by KDIGO2 and NICE3. Glomerular filtration rate (GFR) calculations that are performed by using cystatin C are independent of protein intake, ethnicity and muscle mass2-5. Equations that include cystatin C predict GFR more accurately than serum creatinine in children*6, adults7, and older adults8

Cystatin C with stronger correlation with mGFR:

The graphs below illustrate the stronger correlation observed between cystatin C serum concentrations and iohexol clearance rates relative to that which is seen with creatinine. This improved correlation can be of clinical significance and lead to improved patient care9.

iohexol-cyst-c-and-creatinine

GFR can be estimated with greater accuracy if both cystatin C and creatinine are used. Cystatin C based GFR-estimating equations are superior to creatinine-based equations in predicting end-stage renal disease, cardiovascular manifestations, hospitalisation and death5.

 

Cystatin C immunoassay brochure


The Gentian Cystatin C Immunoassay

  • CE-marked
  • FDA510(k) cleared
  • ERM-DA471/IFCC standardised
  • Clinical chemistry
  • Platform agnostic

Compatible with:

More information - get in touch

Do you want to know more about our Cystatin C immunoassay? If yes, fill out the form below or send an email to marketing@gentian.com

 

Gentian at AACC2020


References

  1. Dharnidharka VR, et al. Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. Am. J. Kidney Dis. 2002;40:221–226.

  2. KDIGO Guidelines 2012 published in Kidney International Supplements Vol3 Issue 1, Jan 2013.

  3. NCIC Clinical guideline (CG182) updated jan 2015 section 2.1 

  4. Tangri N, et al. Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rate. Kidney Int 2011;79:471-7.

  5. Grubb A, et al. Cystatin C is Indispensable for Evaluation of Kidney Disease. eJIFCC 2017 Vol 28 NO4 pp 268-276.

  6. Bjork J et al. Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children. Pediatr Nephrol. 2019;34:1087–1098.

  7. Lesly A. et al. Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C. N Engl J Med 2012;367:20–29.

  8. Schaeffner ES et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med 2012;157:471–481.

  9. Flodin M. et al. Evaluation of Gentian cystatin C reagent on Abbott Ci8200 and calculation of glomerular filtration rate expressed in mL/min/1.73 m(2) from the cystatin C values in mg/L. Scand J Clin Lab Invest. 2007;67(5):560-7.

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