EduWorkShop at EuroMedLab 2019

15. Mar 2019 | 3 min read

EduWorkShop at EuroMedLab 2019

Gentian is looking forward to welcome you to our Educational Workshop at EuroMedlab 21st May 2019, 16:00-17:00, in Barcelona.

Come to learn more about Calprotectin, and discuss Calprotectin as a promising early biomarker for diagnosis of bacterial infections and sepsis.

The workshop


Plasma Calprotectin: A promising early biomarker for the diagnosis of bacterial infections and sepsis.
This educational workshop focuses on the role of calprotectin in early diagnosis of bacterial infections and its performance in differentiation between sepsis and non-infectious causes of systemic inflammation.

Diagnosis of severe infections and sepsis: Challenges with current biomarkers
By Jordi Rello, MD, PhD (Spain)

Calprotectin as a risk marker in emergency department patients with acute dyspnea
By Toralph Ruge, MD, PhD (Sweden)

Educational WS @ EuroMedlab 21st May 2019 16:00-17:00

 

Early diagnosis: bacterial or viral infection?

The rapidly growing problem with antibiotic resistance has resulted in demands for more specific and restrictive use of antibiotics. Biomarkers with ability to diagnose an infection in early stage and distinguish between bacterial and viral infection can possibly reduce overuse of antibiotics.

Importance of early response to bacterial infections

Calprotectin is released upon activation of neutrophils [1] as a part of the early response to bacterial infection. The ability to predict and detect an infection as early as possible, can:

  • aid in a therapeutic decision making
  • add information about diagnosis and risk stratification, which again can
    • reduce the morbidity and mortality
    • improve patient outcome.

Differentiate between SIRS and sepsis
This is especially important in the differentiation between systemic inflammatory response syndrome (SIRS) and sepsis. An early diagnosis of sepsis, and hence an early onset of the appropriate therapy is crucial for the patient outcome [2, 3].

Rapid turn around time
The rapid turn-around-time of a plasma/serum calprotectin test based on the Particle-Enhanced Turbidimetric method combined with the early release of calprotectin upon inflammation and/or infection suggest that calprotectin is a promising biomarker with widespread clinical use.

 

References:

 

  1. Voganatsi A, Panyutich A, Miyasaki KT, Murthy RK. Mechanism of extracellular release of human neutrophil calprotectin complex. J. Leukoc. Biol. 70 (1), 130 –134 (2001).
  2. Kumar A, Roberts D, Wood KE et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 34(6), 1589 –1596 (2006).
  3. Dellinger RP, Levy MM, Rhodes A et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med.39(2), 165–228 (2013).

 

You may also read


Regulatory Affairs Officer

Feb 18, 2020

Regulatory Affairs Officer

Join our team: Regulatory Affairs Officer Please apply through:..

The use of Gentian’s canine CRP immunoassay

Feb 13, 2020

The use of Gentian’s canine CRP immunoassay

CRP is a major acute phase protein in dogs and the measurement of canine CRP is therefore important in..

#FAQ: Avian antibodies – Immunoglobulin Y(IgY)

Jan 23, 2020

#FAQ: Avian antibodies – Immunoglobulin Y(IgY)

Avian antibodies in our commercial products since 2005 Gentian has applied avian antibodies with great..