Calprotectin (S100A8/A9 or MRP8/14) is a promising biomarker for neutrophil activation and inflammation in multiple infections and non-infections inflammatory conditions. Its fast increase in inflammation enables an early and sensitive detection of inflammation and risk stratification.1
Calprotectin, a heterodimer composed of two calcium-binding proteins (S100A8/A9 or MRP8/14), is part of the S100 protein family and is abundantly expressed by white blood cells, particularly neutrophils. Large amounts of stored calprotectin are released from neutrophils during inflammation. This direct and fast upregulation in inflammation makes calprotectin a highly sensitive and early biomarker.
The concentrations of circulating calprotectin correspond to the degree of inflammation. Indications for its use have been reported in both infectious and non-infectious inflammatory conditions.1
Calprotectin is emerging as valuable biomarker in several chronic inflammatory conditions, including rheumatic diseases like Rheumatoid Arthritis, Juvenile Idiopathic Arthritis and Still’s Disease. Locally released calprotectin enters the systemic circulation where it can be measured in serum and plasma, at levels proportional to joint inflammatory activity.2,3
Both the American College of Rheumatology (ACR) and the European Alliance of Associations for Rheumatology (EULAR) in collaboration with the Paediatric Rheumatology European Society (PReS) have highlighted calprotectin as one of the new biomarkers strongly recommended in managing rheumatic diseases.
Namely, calprotectin (S100 protein as inflammatory marker) has been recommended in two first guidelines, regarding the diagnosis of Still’s disease (formerly known as systemic JIA and adult-onset Still’s disease) and the clinical workup up of IL-1 mediated autoinflammatory disease.
GCAL® is a Particle-Enhanced Turbidimetric Immunoassay (PETIA) rapidly performed in only 10 minutes. As open channel assay it is available on a wide range of clinical chemistry platforms.
The assay is not cleared for use in the United States. The assay is CE-marked in compliance with IVDR 2017/746 (CE 0123).
Interested in calprotectin’s clinical utility? Want to learn more about circulating calprotectin?
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* GCAL® is CE-marked under the In Vitro Diagnostic Regulation (IVDR 2017/746, CE 0123). It is not cleared by the U.S. FDA and is not available for sale in the United States.
This material is provided for scientific and educational purposes only and is intended for international use. It does not constitute an offer to sell or distribute GCAL® in the United States.
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