Plasma and serum calprotectin at IFCC EuroMedLab Munich 2022

28. Mar 2022 | 7 min read

Plasma and serum calprotectin at IFCC EuroMedLab Munich 2022

Meet us at EuroMedLab to learn more about calprotectin in plasma and serum

We look forward to exhibit at he XXIV IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine EuroMedLab, in Munich in April 2022.

We hope to see you at our booth #201 to discuss measurement of calprotectin in plasma and serum in the assessment of inflammation and severe infection. 

 

plasma and serum calprotectin


Biomarker for early detection of the inflammatory response to infections

Calprotectin is one of the earliest biomarkers for detection of the inflammatory response to infections1,2. The biomarker is predominantly expressed in neutrophil granulocytes, and it is released upon neutrophil activation in response to inflammation and infection.

Discriminating between bacterial and viral infection

Calprotectin has been reported as diagnostic marker in the discrimination between bacterial and viral infection3, in assessment of severe infections and sepsis4-6 and in the prediction for development of severe infections7. Interestingly, calprotectin has also been reported a risk marker in severe COVID-198,9, which in contrast to other viral infections induce a hyperinflammation response and pathways that mimic bacterial sepsis10.

Biomarker for non-infectious inflammatory diseases, like rheumatic diseases

Calprotectin is also a highly valuable biomarker for non-infectious inflammatory diseases, like rheumatic diseases11. In rheumatoid arthritis (RA) blood calprotectin has been reported to correlate with the inflammation in the arthritic joints and disease severity12.


GCAL® - Plasma and serum calprotectin immunoassay

The Gentian Calprotectin Immunoassay (GCAL®) is the first turbidimetric assay for the quantitative measurement of calprotectin in plasma and serum intended as an aid in the detection and assessment of inflammation. The open channel assay can be applied on a wide range of automated clinical chemistry analysers.

 

plasma and serum calprotectin



Get in touch for information and ordering

Interested in calprotectin for plasma and serum? Want to know more? Please send an email to marketing@gentian.com or fill out the form below:

 

 

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References:

  1. Fullerton J et al. Kinetics of calprotectin, procalcitonin and C-reactive protein in healthy volunteers administered intravenous endotoxin. 40th International Symposium on Intensive Care & Emergency Medicine. Critical Care. 2020. P474.
  2. Jonsson N et al. Calprotectin as an early biomarker of bacterial infections in critically ill patients: an exploratory cohort assessmentCrit Care Resusc. 2017.
  3. Havelka A et al. Calprotectin, a new biomarker for diagnosis of acute respiratory infections. Sci Rep. 2020.
  4. Larsson A et al. Calprotectin is superior to procalcitonin as a sepsis marker and predictor of 30-day mortality in intensive care patientsScand J Clin Lab Invest. 2020.
  5. Jonsson et al. Calprotectin as an early biomarker of bacterial infections in critically ill patients: an exploratory cohort assessment. Crit Care Resusc. 2017.
  6. Simm M et al. Performance of plasma calprotectin as a biomarker of early sepsis: a pilot studyBiomark Med. 2016.
  7. Parke Å et al. Plasma-calprotectin compared with routine biomarkers for prediction of early severe event in sepsis. 40th International Symposium on Intensive Care & Emergency Medicine. Critical Care. 2020.
  8. Bauer W et al. Outcome prediction by serum calprotectin in patients with COVID-19 in the emergency departmentJ Infect. 2021.
  9. Luis García de Guadiana Romualdo et al. Circulating levels of GDF-15 and calprotectin for prediction of in-hospital mortality in COVID-19 patients: A case seriesJ Infect. 2021.
  10. Vincent JL. COVID-19: it's all about sepsisFuture Microbiol. 2021.
  11. Ometto F et al. Calprotectin in rheumatic diseasesExp Biol Med (Maywood). 2017.
  12. Wang Q et al. The Role of Calprotectin in Rheumatoid Arthritis. J Transl Int Med. 2019.

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