Sepsis is the leading cause of death among critically ill patients in intensive care units (ICU) with a continuously increasing incidence and a high mortality rate. Sepsis arises when the body’s response to an infection (bacterial, fungal or viral) starts to injure its own tissues and organs. This response might lead to septic shock with multi-organ failure, and death - especially if not recognised early and treated promptly . You can find more information about sepsis at www.worldsepsisday.org.
SEPSIS - EXPLAINED IN 3 MINUTES
The following video from World Sepsis Day explains sepsis in 3 minutes - including the most common causes, symptoms, how it can be diagnosed and treated, and other useful information.
Calprotectin a promising sepsis biomarker
Calprotectin is a biomarker predominantly expressed in neutrophil granulocytes. It is released upon neutrophil activation in response to inflammation and/or infection. It is also one of the earliest biomarkers for detection of an inflammatory response, as well as for diagnosis of bacterial infections [2,3].
The levels of plasma calprotectin are significantly increased in patients with sepsis. A recent study has shown the ability of calprotectin to distinguish between patients with sepsis and trauma and to predict mortality in the ICU patients. Performance of calprotectin was superior to performance of procalcitonin (PCT) .
Calprotectin is also suggested as a useful biomarker for estimation of disease severity and prediction of severe events in patients with sepsis, including admission to a higher level of care and mortality [2,5].
Need for early diagnosis
Rapid and correct diagnosis is essential in sepsis, as any delay in treatment leads to increased mortality. Calprotectin’s early response to inflammation and infections, combined with turbidimetric technology, will provide faster information and results on patient’s inflammatory response and infection status.
Gentian’s calprotectin Particle-Enhanced Turbidimetric Immunoassay (PETIA), GCAL®, has therefore potential applications for early detection and monitoring of sepsis and other severe bacterial infections, where it is critical to get fast access to results. GCAL® is rapidly performed in only 10 minutes and can be applied on a wide range of automated clinical chemistry analysers.