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Gentian Retinol-Binding Protein (RBP) Immunoassay

Quantitative determination of Retinol-Binding Protein levels in serum and plasma using turbidimetric technology. 

Retinol-Binding Protein (RBP) is a carrier protein of vitamin A (retinol) in blood, produced and stored mainly in the liver. The concentration of RBP in the circulation remains mostly constant in healthy individuals, though the levels can be altered in many conditions and disorders1-8, such as;  

  • Vitamin A deficiency
  • Undernutrition
  • Diabetes
  • Renal dysfunction

#DiagnosticEfficiency (5)

 

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Interested in validation of RBP in your lab?

References: 

  1. Steinhoff, J.S., A. Lass, and M. Schupp, Biological Functions of RBP4 and Its Relevance for Human Diseases. Front Physiol, 2021. 12: p. 659977.
  2. Flores-Cortez, Y.A., et al., Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). Mol Med Rep, 2022. 26(1).
  3. Tanumihardjo, S.A., et al., Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. J Nutr, 2016. 146(9): p. 1816s-48s.
  4. Steinhoff, J.S., A. Lass, and M. Schupp, Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease. Nutrients, 2022. 14(6).
  5. de Pee, S. and O. Dary, Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein. J Nutr, 2002. 132(9 Suppl): p. 2895s-2901s.
  6. Sergi, G., et al., Role of visceral proteins in detecting malnutrition in the elderly. Eur J Clin Nutr, 2006. 60(2): p. 203-9.
  7. Zhang, L., et al., The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis. Dis Markers, 2020. 2020: p. 8830471.
  8. Nono Nankam, P.A. and M. Blüher, Retinol-binding protein 4 in obesity and metabolic dysfunctions. Mol Cell Endocrinol, 2021. 531: p. 111312.

 

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