Mini-webinar: Can cystatin C eGFR improve accuracy in kidney care?
03. Jan 2024 |
4 min read
In the series of mini-webinars on cystatin C and kidney health our Global Product Manager for Cystatin C Mr. Gaute Tangen focuses on cystatin C eGFR as a potential enhancer of accuracy and reliability of estimating kidney function.
The biomarker cystatin C
Cystatin C is produced at a constant rate and freely filtered by the kidneys. The biomarker is less influenced by factors like age, gender or muscle mass compared to creatinine. Therefore, using cystatin C, combined with or instead of creatinine, might offer a more accurate estimations of kidney function, particularly in populations where testing with creatinine can be less reliable.
Research and studies conducted by the European Kidney Function Consortium (EKFC) and other groups have explored the utility of cystatin C as a biomarker for kidney function estimation without the inclusion of race and sex. By integrating cystatin C into the EKFC equation for estimating GFR, there's a potential for heightened accuracy.
Watch webinar: Can cystatin C eGFR improve accuracy in kidney care?
Cystatin C in European Kidney Function Consortium (EKFC) equation
The European Kidney Function Consortium (EKFC) developed the creatinine-based equation (EKFC eGFRcr) to estimate GFR in the early 2000s. The creatinine-based equation aimed to standardise the estimation of GFR by adjusting the serum creatinine level to account for variations related to age, sex, or race.
Resent research conducted across cohorts from Europe, the United States, and Africa demonstrates that the newly developed cystatin C-based equation (EKFC eGFRcys) shows improved accuracy in assessing GFR compared to commonly used equations. The advantage of this equation stemmed from cystatin C's properties as a biomarker less influenced by factors like age, sex, or muscle mass, making it potentially more reliable in estimating kidney function across diverse populations.
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