Calprotectin for detection of the inflammatory response to infections
30. Aug 2021 |
8 min read
Calprotectin in blood: An early marker for the detection of the inflammatory response to infections1,2
Calprotectin is a neutrophilic protein released in the inflammatory response. The biomarker is part of the first line defence to infections, and also has anti-microbial and pro-inflammatory properties. As a biomarker calprotectin can give early indications of an inflammatory reaction and the concentration of calprotectin in blood reflects the degree of inflammation.
The value of calprotectin in infection
Differentiates between bacterial and viral infections3,4
Predicts serious events in critically ill patients2,5
Superior to traditional biomarkers for prediction of severe events in clinical sepsis5
Calprotectin levels can indicate current and future severity in COVID-19 patients6,7
Severe events in infections
Calprotectin has shown to be a useful biomarker for prediction of early severe events in sepsis. A recent study has shown that the level of plasma calprotectin is significantly higher in sepsis patients who subsequently developed severe events. This study also indicates that plasma calprotectin performs better than traditional biomarkers such as procalcitonin (PCT), neutrophil-lymphocyte-ratio and C-reactive protein (CRP) for prediction of severe events in patients with sepsis5.
Helps to identify which patients need antibiotic treatment2,3
Differentiates between sepsis and trauma8
Can be used in patients with liver disease and pediatric population9-11
Can be used in patients treated with IL-6 inhibitors and TNF12-13
Gentian Calprotectin GCAL® Immunoassay - early access to accurate results
GCAL® can be used for early detection and assessment of the inflammatory response to severe infections, where it is critical to get access to the results as soon as possible. Since GCAL® is a Particle-Enhanced Turbidimetric Immunoassay (PETIA), the assay is rapidly performed in only 10 minutes.
Contact us now for more information
Do you have questions about GCAL® or is interested in validation? Please send an email to email@example.com or fill out the form below: