The complexity of the skin disease Hidradenitis Suppurativa (HS) and the role of proinflammatory signalling in this disease were extensively discussed at the 13th Conference of the European Hidradenitis Suppurativa Foundation (EHSF) in Lyon, France.
Gentian has, in collaboration with Professor Evangelos Giamarellos-Bourboulis from the University of Athens, initiated a study to explore the correlation of circulating calprotectin levels with the activity and severity of the disease. The circulating calprotectin levels were measured with the Gentian GCAL® Calprotectin Immunoassay. Data from the study was presented at the EHSF conferences as a poster.
The importance of early biological treatment in Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin condition impacting the apocrine sweat glands. Draining tunnel (dT) formation is the hallmark of HS in the affected skin. The disease can cause severe scarring and disability, placing a significant and often underestimated burden on patients. Diagnosis is mainly relying on patient reporting and visible outbreaks. A biomarker which predicts dT formation before their appearance in the skin could become a valuable tool for early biological treatment.
“Early intervention in HS is crucial to prevent the formation of severe scars in affected skin but predicting the course and advancement of the disease is challenging.“
Aleksandra Havelka, CSO, Gentian Diagnostics
The study – Calprotectin as a biomarker of severe inflammation and draining tunnel formation in hidradenitis suppurativa
Circulating calprotectin has been proven as an early biomarker for detection of inflammation and estimation of disease activity in various inflammatory conditions. Building on this previous knowledge of calprotectin in inflammatory conditions, the study in Athens aims to elucidate the value of calprotectin in HS disease classification and estimation of disease severity, prediction of development of draining tunnels and treatment monitoring.
Data presented at the EHSF conference confirms the correlation of calprotectin levels with the disease activity and severity of the disease, measured by number of draining tunnels and iHS4 (International HS 4 score). Calprotectin’s use as surrogate of early start of biologicals and response to treatment is subject of the currently ongoing part of the study.
"We believe that calprotectin could serve as a valuable tool for the early identification of severe HS, offering guidance for treatment initiation and monitoring, and potentially preventing severe inflammation and development of extensive scarring in affected skin."
Aleksandra Havelka, CSO, Gentian Diagnostics
Gentian GCAL® Calprotectin Immunoassay
The Gentian GCAL® Calprotectin Immunoassay is the first turbidimetric assay for the quantitative measurement of calprotectin in plasma and serum intended as an aid in the detection and assessment of inflammation and inflammatory response to infections. The open channel assay can be applied on a wide range of automated clinical chemistry analysers.
GCAL® is CE-marked and IVDR certified.
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