NKF-ASN Task Force: Recommends increased use of cystatin C

24. Sep 2021 | 4 min read

NKF-ASN Task Force: Recommends increased use of cystatin C

NKF-ASN Task Force: Recommends increased use of cystatin C as a confirmatory assessment of GFR

The NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease recommends increased use of cystatin C as a confirmatory assessment of GFR as part of a race-free approach to diagnosing kidney disease.

A disproportionate number of the 37 million Americans that have kidney disease are of African American, Hispanic, Asian, or Native American descent. The use of race modifiers in the clinical algorithms used to detect and manage kidney disease have contributed to major kidney-health disparities among these ethnic minority groups.

 

NKF-ASN Task Force: Reassessing the Inclusion of Race in Diagnosing Kidney Diseases  

On July 2, 2020, the National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) announced the formation of a joint task force to reassess the inclusion of race in diagnosing kidney disease. As part of this initiative, the two organisations set out to:

  1. achieve a consensus on replacing race-based equations for estimating glomerular filtration rate (eGFR);
  2. assess the challenges brought on by implementing alternative methods; and 
  3. make recommendations as to the best approach for replacing current eGFR equations. 

Based on input collected over 10 months from hundreds of patients, patient advocates, medical students, clinicians and scientists, ­­the task force published its final report on September 23, 2021, recommending the "increased use of cystatin C combined with serum creatinine, as a confirmatory assessment of GFR or kidney function."

 

Cystatin C as a marker of kidney function

One key advantage of measuring cystatin C in addition to creatinine stems from the fact that cystatin C is less susceptible to factors that affect muscle mass (age, diet, sex, physical activity, etc.). Cystatin C is ubiquitously expressed through all nucleated cells. Individuals with similar kidney function can therefore be expected to have similar serum concentrations of cystatin C. This means that equations used for calculating GFR do not depend on an individual’s muscle mass or race.

 

Get in touch

If you and your colleagues would like to learn more about cystatin C and how you could incorporate this test into clinical workflows within your organization, please contact us via marketing@gentian.com or fill out the form below: 

You may also read


Gentian showcases diagnostic research at EuroMedLab 2025

May 20, 2025

Gentian showcases diagnostic research at EuroMedLab 2025

Posters: Retinol-Binding Protein and NT-proBNP At EuroMedLab 2025 in Brussels, Gentian Diagnostics will..

Canine CRP assay at EuroMedLab 2025

May 14, 2025

Canine CRP assay at EuroMedLab 2025

Learn more about Gentian's turbidimetric canine CRP assay at booth #115 Gentian Diagnostics will also this..

Gentian @ EuroMedLab 2025: Raising the standard in inflammation testing with GCAL®

May 12, 2025

Gentian @ EuroMedLab 2025: Raising the standard in inflammation testing with GCAL®

GCAL® Calprotectin – A new standard in inflammation testing At EuroMedLab 2025 in Brussels, Gentian..