--- title: Gentian showcases diagnostic research at EuroMedLab 2025 description: Posters at Euromedlab 2025. NT-proBNP adn Retinol-binding protein image: https://www.gentian.com/hubfs/Exhibitions-805x403(51).jpg --- ![Gentian showcases diagnostic research at EuroMedLab 2025](https://www.gentian.com/hubfs/Exhibitions-805x403(51).jpg) ## Posters: Retinol-Binding Protein and NT-proBNP **At EuroMedLab 2025 in Brussels, Gentian Diagnostics will present two scientific posters showcasing our latest research:** - **[NT-proBNP (in development)](https://www.gentian.com/products/nt-probnp-turbidimetric-assay):** A novel assay for improved detection and monitoring of heart failure - [**Retinol-Binding Protein (RBP):**](https://www.gentian.com/products/retinol-binding-protein-rbp) An assay designed to support nutritional status evaluation and renal function assessment ## Poster: Addressing glycosylation bias in NT-proBNP testing The poster 0356 *"Development and characteristics of immunoturbidimetric NT-proBNP assay based on antibodies targeting glycosylation-free regions of NT-proBNP"* focuses on Gentian’s novel approach to NT-proBNP quantification. Current immunoassays use antibodies that bind to the central region of NT-proBNP, which is usually glycosylated. Glycosylation of NT-proBNP restricts the binding of the antibodies and detection of the protein. It has been shown that up to 80% of the circulating NT-proBNP may be glycosylated in the central region. Gentian’s proto-type assay is designed to overcome this underestimation by using antibodies targeting **glycosylation-free regions** of the molecule.   ### Key findings from the Gentian NT-proBNP proto-type assay study: - Enzymatic deglycosylation by glycosidase treatment had no significant effect on measured values, confirming the assay detects total NT-proBNP regardless of glycosylation status - Strong analytical performance with compatibility across major instrument platforms like Mindray and Beckman Coulter Measuring** **NT-proBNP, independent of glycosylation status, potentially offers more accurate assessment of heart failure in diverse patient populations. Ongoing studies aim to further explore the clinical utility of this approach.   [![NT-proBNP](https://www.gentian.com/hs-fs/hubfs/CTA(4).png?width=800&height=250&name=CTA(4).png)](mailto:marketing@gentian.com)   ## Poster: Establishing a reference range for Gentian's RBP assay In the poster 2423 *"Establishment of a Reference Range for Gentian Retinol Binding Protein (RBP) Assay Using Beckman Coulter DxC 700 AU Analyzer"*, Gentian presents a comprehensive reference range study for its RBP assay. RBP plays a dual role as a biomarker for vitamin A deficiency and renal dysfunction, making it valuable in both nutritional and nephrological assessments. ### Highlights from the study: - A reference range of 24–62 mg/L was established for the Gentian RBP assay, slightly broader than previously reported values - Separate ranges were calculated for males (22–61 mg/L) and females (19–57 mg/L), suggesting potential sex-based differences warranting further analysis - No significant differences were found between fresh and frozen samples, or between serum, lithium-heparin plasma, and EDTA plasma, confirming the assay’s robustness across sample types and storage conditions These results underscore the importance of assay-specific reference validation to ensure accurate clinical interpretation of RBP levels. [![RBP - Retinol-Binding Protein](https://no-cache.hubspot.com/cta/default/6752890/4e27988a-8feb-407c-a3f1-976ebe4ce606.png)](https://cta-redirect.hubspot.com/cta/redirect/6752890/4e27988a-8feb-407c-a3f1-976ebe4ce606)   ## Meet the Gentian team at booth #115 Visit us at **booth #115** to learn more about our full range of diagnostic assays and ongoing scientific developments. 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