New turbidimetric Retinol-Binding Protein (RBP) immunoassay

Quantitative determination of Retinol-Binding Protein levels in plasma and serum

Retinol-Binding Protein (RBP or RBP4) is a transport protein for retinol (vitamin A) in blood, synthesised in the liver and almost completely reabsorbed in the kidney.^{[1, 2]} The concentration of RBP in blood remains mostly constant in healthy individuals, though the levels can be altered in many conditions and disorders such as vitamin A deficiency, undernutrition, diabetes and renal dysfunction. The RBP levels are elevated in patients with diabetes and renal dysfunction and reduced in conditions such as vitamin A deficiency and undernutrition.^1,2

Diagnostic value 

The diagnostic value lies in altered levels of circulating RBP in many conditions, including:

Vitamin A deficiency^2-5

Increasing prevalence of vitamin deficiency due to smoking, sedentary lifestyle, consumption of unhealthy food and alcohol

Undernutrition^6-8

Growing geriatric population contributes to number of patients with undernutrition

Diabetes^9-13

With aging populations, a global increase in the incidence of chronic diseases such as diabetes is observed 

Renal dysfunction^14-17

Rising prevalence of hypertension, type 2 diabetes, rising prevalence of kidney disease, and fast-growing geriatric population.

Potential target patient groups:

Advantages: the Gentian Retinol-Binding Immunoassay

Gentian Retinol-Binding Protein Immunoassay is a turbidimetric assay that is rapidly performed in only 10 minutes. The assay is instrument independent and can be applied on a wide range of automated clinical chemistry analysers.

• Turbidimetric assay for serum and plasma
• Instrument-independent
• High-throughput analysis with standard core lab workflow
• Ready-to-use Reagent Kit, Calibrator Kit and Controls
• CE-marked and UKCA-marked
• FDA 510 (k) exempt
• Manufactured according to ISO 13485:2016

Contact us for further information

Explore RBP in your laboratory - fill out the form below or send an email to marketing@gentian.com for more information about the product and prices.

^References:

1. Steinhoff JS et al. Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease. Nutrients, 2022
2. Tanumihardjo SA et al. Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. J Nutr, 2016
3. Gamble MV et al. Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A-deficient children from the Republic of the Marshall Islands. Am J Clin Nutr, 2001
4. de Pee S et al. Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein. J Nutr, 2002
5. Talsma EF et al. Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study. BMC Med, 2015
6. Smith FR et al. Plasma vitamin A, retinol-binding protein and prealbumin concentrations in protein-calorie malnutrition. III. Response to varying dietary treatments. Am J Clin Nutr, 1975
7. Sergi G et al. Role of visceral proteins in detecting malnutrition in the elderly. Eur J Clin Nutr, 2006
8. Pisprasert V et al. Moderately high-protein enteral formula improved retinol-binding protein in tube-fed patients: A multicentre open study. Nutr Health, 2017
9. Olsen T et al. Retinol, Retinoic Acid, and Retinol-Binding Protein 4 are Differentially Associated with Cardiovascular Disease, Type 2 Diabetes, and Obesity: An Overview of Human Studies. Adv Nutr, 2020
10. Nono Nankam PA et al. Retinol-binding protein 4 in obesity and metabolic dysfunctions. Mol Cell Endocrinol, 2021
11. Steinhoff JS et al. Biological Functions of RBP4 and Its Relevance for Human Diseases. Front Physiol, 2021
12. Flores-Cortez YA et al. Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). Mol Med Rep, 2022
13. Mousavi SN et al. Association of Leptin and Retinol Binding Protein 4 with the Risk of Gestational Diabetes: A Systematic Review and Meta-Analysis of Observational Studies. Indian J Endocrinol Metab, 2023
14. Zhang L et al. The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis. Dis Markers, 2020
15. Zhang WX et al. Decreased retinol-binding protein 4 in the sera of patients with end-stage renal disease after kidney transplantation. Genet Mol Res, 2014
16. Xun C et al. Circulating RBP4 Increase and Its Diagnosis of Chronic Kidney Disease. Ann Clin Lab Sci, 2018
17. Ye Z et al. Correlation and Diagnostic Value of Serum Cys-C, RBP4, and NGAL with the Condition of Patients with Traumatic Acute Kidney Injury. Evid Based Complement Alternat Med, 2021