---
title: New turbidimetric Retinol-Binding Protein (RBP) immunoassay
description: New turbidimetric Retinol-Binding Protein (RBP) immunoassay
image: https://www.gentian.com/hubfs/social%20media%20805x403(4)-1.png
---

![New turbidimetric Retinol-Binding Protein (RBP) immunoassay](https://www.gentian.com/hubfs/social%20media%20805x403(4)-1.png)

## Quantitative determination of Retinol-Binding Protein levels in plasma and serum

Retinol-Binding Protein (RBP or RBP4) is a transport protein for retinol (vitamin A) in blood, synthesised in the liver and almost completely reabsorbed in the kidney.[1, 2] The concentration of RBP in blood remains mostly constant in healthy individuals, though the levels can be altered in many conditions and disorders such as vitamin A deficiency, undernutrition, diabetes and renal dysfunction. The RBP levels are elevated in patients with diabetes and renal dysfunction and reduced in conditions such as vitamin A deficiency and undernutrition.1,2

 

## Diagnostic value 

The diagnostic value lies in altered levels of circulating RBP in many conditions, including:

### Vitamin A deficiency2-5

Increasing prevalence of vitamin deficiency due to smoking, sedentary lifestyle, consumption of unhealthy food and alcohol

### Undernutrition6-8

Growing geriatric population contributes to number of patients with undernutrition

### Diabetes9-13

With aging populations, a global increase in the incidence of chronic diseases such as diabetes is observed 

### Renal dysfunction14-17

Rising prevalence of hypertension, type 2 diabetes, rising prevalence of kidney disease, and fast-growing geriatric population.

 

## Potential target patient groups:

| ### Vitamin A deficiency - Symptoms of vitamin A deficiency - Developing countries (replacing HPLC) - Undernourished patients | ### Diabetes - Suspected of developing diabetes - Obesity - Screening of pregnancy-related diabetes |
| --- | --- |

| ###  Undernutrition - Geriatric population - Disorders or on treatment affecting nutritional absorbance - Pediatric cancer - General health profile screening - Eating disorders or alcoholism | ### Renal dysfunction - Kidney failure - Individuals at risk of developing kidney failure - ICU for screening purposes |
| --- | --- |

 

[![RBP - Retinol-Binding Protein](https://no-cache.hubspot.com/cta/default/6752890/4e27988a-8feb-407c-a3f1-976ebe4ce606.png)](https://cta-redirect.hubspot.com/cta/redirect/6752890/4e27988a-8feb-407c-a3f1-976ebe4ce606)

## Advantages: the Gentian Retinol-Binding Immunoassay

Gentian Retinol-Binding Protein Immunoassay is a turbidimetric assay that is rapidly performed in only 10 minutes. The assay is instrument independent and can be applied on a wide range of automated clinical chemistry analysers.

- Turbidimetric assay for serum and plasma
- Instrument-independent
- High-throughput analysis with standard core lab workflow
- Ready-to-use Reagent Kit, Calibrator Kit and Controls
- CE-marked and UKCA-marked
- FDA 510 (k) exempt
- Manufactured according to ISO 13485:2016

 

[![New call-to-action](https://no-cache.hubspot.com/cta/default/6752890/4f0333c4-e13b-422d-82f4-589957fbb176.png)](https://cta-redirect.hubspot.com/cta/redirect/6752890/4f0333c4-e13b-422d-82f4-589957fbb176)

 

## Contact us for further information

**Explore RBP in your laboratory - fill out the form below or send an email to [marketing@gentian.com](mailto:marketing@gentian.com) for more information about the product and prices.**

 

 

### References:

1. Steinhoff JS et al. *Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease.* Nutrients, 2022
2. Tanumihardjo SA et al. *Biomarkers of Nutrition for Development (BOND)-Vitamin A Review.* J Nutr, 2016
3. Gamble MV et al. *Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A-deficient children from the Republic of the Marshall Islands.* Am J Clin Nutr, 2001
4. de Pee S et al. *Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein.* J Nutr, 2002
5. Talsma EF et al. *Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study.* BMC Med, 2015
6. Smith FR et al. *Plasma vitamin A, retinol-binding protein and prealbumin concentrations in protein-calorie malnutrition. III. Response to varying dietary treatments.* Am J Clin Nutr, 1975
7. Sergi G et al. *Role of visceral proteins in detecting malnutrition in the elderly.* Eur J Clin Nutr, 2006
8. Pisprasert V et al. *Moderately high-protein enteral formula improved retinol-binding protein in tube-fed patients: A multicentre open study.* Nutr Health, 2017
9. Olsen T et al. *Retinol, Retinoic Acid, and Retinol-Binding Protein 4 are Differentially Associated with Cardiovascular Disease, Type 2 Diabetes, and Obesity: An Overview of Human Studies.* Adv Nutr, 2020
10. Nono Nankam PA et al. *Retinol-binding protein 4 in obesity and metabolic dysfunctions.* Mol Cell Endocrinol, 2021
11. Steinhoff JS et al. *Biological Functions of RBP4 and Its Relevance for Human Diseases.* Front Physiol, 2021
12. Flores-Cortez YA et al. *Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review).* Mol Med Rep, 2022
13. Mousavi SN et al. *Association of Leptin and Retinol Binding Protein 4 with the Risk of Gestational Diabetes: A Systematic Review and Meta-Analysis of Observational Studies.* Indian J Endocrinol Metab, 2023
14. Zhang L et al. *The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis.* Dis Markers, 2020
15. Zhang WX et al. *Decreased retinol-binding protein 4 in the sera of patients with end-stage renal disease after kidney transplantation.* Genet Mol Res, 2014
16. Xun C et al. *Circulating RBP4 Increase and Its Diagnosis of Chronic Kidney Disease.* Ann Clin Lab Sci, 2018
17. Ye Z et al. *Correlation and Diagnostic Value of Serum Cys-C, RBP4, and NGAL with the Condition of Patients with Traumatic Acute Kidney Injury.* Evid Based Complement Alternat Med, 2021

 

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