In the series of mini-webinars on cystatin C and kidney health our Global Product Manager for Cystatin C Mr. Gaute Tangen focuses on cystatin C eGFR as a potential enhancer of accuracy and reliability of estimating kidney function.
The biomarker cystatin C
Cystatin C is consistently generated and easily filtered by the kidneys. Unlike the more wieldy used biomarker creatinine, it is less affected by variables such as age, gender, or muscle mass. Consequently, incorporating cystatin C into kidney function assessments, either in conjunction with or instead of creatinine, may provide more precise estimations, especially in populations where creatinine testing may be less dependable (children, amputees, elderly, athletes).
Mini-webinar:
eGFR equations for multi-ethnic Asian populations
Cystatin C, alone or in combination with creatinine, provides a more accurate eGFR. Increased Cystatin C concentration is associated with an increased risk of death and end-stage renal disease across diverse populations. The study discussed in this mini-webinar seeks to assess the performance of eGFR equations in Asia, considering age groups, disease conditions, and ethnicity. Specifically, to see the performance of equations utilising creatinine and cystatin C biomarkers individually and in combination across diverse age groups and disease conditions in various Asian ethnicities.1
WATCH ON YOUTUBE
eGFR equations: One size does not fit all
There are several resents articles that have looked at equations for different populations, showing that one size does not fit all. One example is this article for the Pakistani population: Comparison of Pakistani CKD-EPI, new Asian-modified CKD-EPI and revised Lund-Malmö study equations in a South Asian CKD population: a study from a Pakistani CKD cohort written by the same authors as the mini-webinar above2.
Watch other mini-webinar discussing equations for different populations:
Can cystatin C eGFR improve accuracy in kidney care?
Disparities in kidney care and the role of cystatin C
Cystatin C, Creatinine and eGFR Equations
The Gentian Cystatin C Immunoassay
The Gentian Cystatin C Immunoassay (ERM-DA471/IFCC standardised) is an open channel turbidimetric test for quantitative analysis of cystatin C in human serum and plasma. The assay received FDA 510(k) clearance in 2008. It is CE-marked and complies with the European In-Vitro Diagnostic Regulation (IVDR), EU 2017/746.
- ERM-DA471/IFCC standardised
- FDA510 (k) cleared
- IVDR certified
- Available for a wide range of clinical analysers (open channel assay)
- Particle-Enhanced Turbidimetric Immunoassay (PETIA)
- Rapidly performed in only 10 minutes
- Avian antibodies – Less interference
Contact Gentian for more information about cystatin C
Get in touch with our Product Manager for cystatin C for product specification and pricing. Fill out the form below or send an email to marketing@gentian.com.
References:
Safdar A et al. Optimal Glomerular Filtration Rate Equations for Various Age Groups, Disease Conditions and Ethnicities in Asia: A Systematic Review. J Clin Med. 2023
Safdar A et al. Comparison of Pakistani CKD-EPI, new Asian-modified CKD-EPI and revised Lund-Malmö study equations in a South Asian CKD population: a study from a Pakistani CKD cohort. J Nephrol. Published online August 30, 2023
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