FAQ: The clinical value of calprotectin in sepsis & severe infections?
19. Mar 2021 |
9 min read
Prediction of severe events in clinical sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is the most frequent cause of admission to ICU and the most common cause of death in critically ill patients1. Rapid and correct diagnosis is very important in sepsis, as any delay in treatment will increase mortality. Since sepsis is often associated with non-specific symptoms it is difficult to diagnose2. In addition, prediction of severe events in clinical sepsis is challenging and of great importance for correct treatment and care of the affected patients.
Multiple studies have shown that calprotectin levels are elevated in patients with severe infection and sepsis, and confirms that calprotectin can accurately diagnose sepsis6-10. In addition, calprotectin can be a predictive biomarker for the development of severe infection8,11,12 and baseline levels in sepsis patients as well as changes in calprotectin can be predictive for patient outcome6,7,9,10,13. Importantly, calprotectin has shown to be able to distinguish between viral and bacterial infection14-16 which is crucial for decisions and about the course of treatment and antibiotic use.
Moreover, calprotectin has also been reported to be earlier and superior biomarker in severe infection compared to other inflammatory markers, like C-reactive protein (CRP), procalcitonin (PCT) and heparin-binding protein (HBP), in diagnosis, prediction and distinction between viral infection and bacterial infection5-7,12,14.
Calprotectin and sepsis:
Severe infections and sepsis are a life threating global health burden
Calprotectin is an early and sensitive biomarker upregulated in the inflammatory response to infections
Calprotectin measurements can assess the development and course of severe infections
Calprotectin can reliably distinguish between viral and bacterial infections
Do you have questions about GCAL® or calprotectin in severe infections? Send an email firstname.lastname@example.org fill out the form below and our Product Manager for GCAL® will answer your questions.